Mr. Yasuyoshi Mizutani received the 2024 (26th) Acta Histochemica et Cytochemica Award. The award ceremony was held at the 65th Annual Meeting of the Japan Society of Histochemistry and Cytochemistry on October 26th, 2024.

Yasuyoshi Mizutani, Kazuya Shiogama, Ken-ichi Inada, Toshiyuki Takeuchi, Atsuko Niimi, Motoshi Suzuki, Yutaka Tsutsumi. Enzyme-labeled Antigen Method: Factors Influencing the Deterioration of Antigen-binding Activity of Specific Antibodies during Formalin Fixation and Paraffin Embedding. Acta Histochemica et Cytochemica. 55(5):129-148, 2022.(https://doi.org/10.1267/ahc.22-00023)

From Silapakorn University, Thailand, we have accepted an exchange student Chayanit Pattanapong, the third lady from the left. She will be at our lab for 12 weeks.

On the Feb 9th, Dr. Siwanon Jirawatnotai visited us from Mahidol University, Thailand. He gave us a wonderful lecture entitled 'Capitalizing the cancer dynamic re-wiring for cholangiocarcinoma therapy'. We thank him very much for the fruitful discussion with graduate students.

On the Nov 17th, Dr. MeiChee Tai visited us from Cancer Research Malaysia. She gave us a wonderful lecture entitled 'Polygenic risk scores for prediction of breast cancer risk in Asian populations'. We discussed lots of things. Thank you!

From Silapakorn University, Thailand, we have accepted an exchange student Nichapat, the third lady from the left. She will be at our lab for 12 weeks.

*1)　Suzuki M et al. CERS6 required for cell migration and metastasis in lung cancer. J Clin Mol Med, 24: 11949-11959, 2020.
*2)　Shi H et al. CEBPgamma facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. Cancer Sci 112:2770-2780, 2021.

'Alanine-serine-cysteine transporter 2 inhibition suppresses prostate cancer cell growth in vitro', a collaboration project with Dr.Masanobu Saruta at Fujita Health University,has been accepted by the JCM.

'Enzyme-labeled antigen method: factors influencing the deterioration of antigen-binding activity of specific antibodies during formalin fixation and paraffin embedding', has been accepted by the Acta Histochemica et Cytochemica. We sincerely thank collaborators and other persons who supported this project.

'Antitumor effect of polyphyllin D on liver metastases of Neuroblastoma', a collaboration project with Drs. Tatsuya Suzuki at Fujita Health University and Seiji Okada at Kumamoto University, has been accepted by the Pediatric Surgery International.

We have new lab members, Siripan Limsirichaikul from Thailand and Tran Quoc Dat from Vietnam.

'Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells',　a collaboration project with Dr. Keiko Tamiya-Koizumi at Nagoya City University, has been accepted by the Biochemical and Biophysical Research Communications.

'Adipsin-dependent secretion of hepatocyte growth factor regulates the adipocyte-cancer stem cell interaction ', a collaboration project with Dr. Yohei Shimono at Fujita Health University, has been accepted by the Cancers.

'Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas ', a collaboration project with Dr.Kazuhiko Kuwahara at Fujita Health University Hospital, has been accepted by the Laboratory Investigation.

’CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation’ has been accepted by the Cancer Science. We sincerely thank collaborators and other persons who supported this project.

'Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator' a collaboration project with Dr.Takashi Takahashi at Aichi Cancer Center, has been accepted by the Cancer Science.

From Thailand a graduate student Patinya Sawangsri has joined our lab. We sincerely hope covid-19 epidemic calms down soon.

'Inhibition of HSP90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma', a collaboration project with Dr.Takashi Takahashi at Aichi Cancer Center, has been accepted by the Cancer Science.

'Upregulation of S100A10 in metastasized breast cancer stem cells', a collaboration project with Dr. Shimono at Department of Biochemistry of this University, has been accepted by the Cancer Science.

'CERS6 required for cell migration and metastasis in lung cancer', has been accepted by the Journal of Cellular and Molecular Medicine. We sincerely thank collaborators and other persons who supported this project.

For summer holidays, undergraduate students have come and played with a research project. They are performing an immuno-histochemical experiments.

'Vaticanol C, a Phytoalexin, Induces Apoptosis of Leukemia and Cancer Cells by Modulating Expression of Multiple Sphingolipid Metabolic Enzymes', a collaboration project with Dr.Takashi Murate at Chubu University, has been accepted by the Nagoya J Med Sci.

'Combined α-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 inandrogen-receptor-variant-7-positive-prostate cancer cells', a collaboration project with Drs. Shiroki, Takahara, Yoshizawa at Department of Urology, has been accepted by the Prostate International.