Case 187. Hand-foot-and-mouth disease (1 y-o F)

       
  Multiple vesicular lesions on the oral cavity, hip and extremities (biopsy from the leg skin)  
       

 

  Closer view of the intraepidermal spongiotic vesicles (HE, higher power). Hand-foot-and-mouth disease is caused by infection of Coxsackie virus A19 or enterovirus 71. In the latter case, encephalitic complication is problematic. Refer to case 115.