Case 121. 

JC virus infection (progressive multifocal leukoencephalopathy) (35 y-o F)

       
  Progressive deterioration of brain functions in case of SLE receiving corticosteroid  
       

 

  Multifocal demyelinated foci are seen in the white matter of the cerebral hemisphere (LFB-HE, low power). PML, caused by papova virus reactivation, is a representative CNS lesion in AIDS.