Case 113. 

Gerstmann-Straussler-Scheinker (GSS) disease (54 y-o F)
　 　 　 　
　
Familial progressive dementia with spastic paralysis (clinical course 23 years)
 　
　 　 　 　

　

 　 The neurofibrillary tangle is immunoreactive for tau protein revealed by immunostaining. This is a special subtype of GSS disease with neurofibrillary changes.