Case 112. Creuzfeldt-Jakob's disease (60 y-o F)

　 　 　 　
　
Autopsied brain from a patient with progressive dementia and ankylosis
 　
　 　 　 　

　

 　 The spongy state is typically observed in the deep part of the cerebral cortex (LFB-HE, high power). Spongiform encephalopathy represents a histological feature of prion disease.