Case 78. Reference case 78A

　 　 　 　
　 Brushing cytology showing a multinucleated giant cell which phagocytizes round yeasts into the cytoplasm (Papanicolaou). 　
　 　 　 　

　

 　 Cryptococcus neoformans proliferate within the cell, and the main defense mechanism against this yeast is the cellular immunity.