Case 78. Cryptococcal granuloma of lung (49 y-o M)

　 　 　 　
　
Solitary subpleural lung nodule excised thoracoscopically
 　
　 　 　 　

　

 　 Multinucleated giant cells contain numbers of haloed, unstained yeasts, Cryptococcus neoformans (HE). Fibroblastic activation is associated with the granulomatous reaction.