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Case 220. CMV villitis (25 y-o F)
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| Placental tissue artifically aborted at the 20th week of gestation, accompanying high CMV antibody titer in mother and a microcephalic baby (465 g) |
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Key words : cytomegalovirus, villitis, microcephalus
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| Cytomegalic inclusion bodies are seen in the nuclei of Hofbauer cells in the placental villi (HE). Fetal infection of CMV was confirmed by autopsy. | In situ hybridization histochemistry for DNA of CMV reveals positive signals in the inclusion bodies. | |
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| The cytoplasmic granular inclusions are immunoreactive for Leu M1 (CD15). Nuclear inclusions are negative. | ||
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