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Case 121.
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JC virus infection (progressive multifocal leukoencephalopathy) (35 y-o F) |  |
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| Progressive deterioration of brain functions in case of SLE receiving corticosteroid |
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Key words :
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progressive multifocal leukoencephalopathy, demyelination, JC virus, steroid | ||||
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opportunistic infection
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| Multifocal demyelinated foci are seen in the white matter of the cerebral hemisphere (LFB-HE, low power). PML, caused by papova virus reactivation, is a representative CNS lesion in AIDS. | Oligodendroglial cells contain pyknotic nuclei and nuclear inclusion bodies. Reactive astroglial cells are seen (LFB-HE, high power). | |
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| JC viral antigen is demonstrated in the nuclear inclusions and in some glial fibers (immunostaining). | ||
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