 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
||||||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|
|||||||||
 |
|
||||||||||||||||
 |
 |
 |
 |
 |
 |
|
|||||||||||
 |
|
||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
 |
Case 117. VZV encephalitis in AIDS (40 y-o M)
|
 |
 |
|
Fatal necrotizing encephalitis manifested after healing of herpes zoster
|
|
Key words : varicella-zoster virus, necrotizing encephalitis, AIDS
|
|
opportunistic infection
|
 |
 |
|
| Massive and fused necrosis is seen mainly in the cerebral cortex of the left hemisphere (a frontal section after formalin fixation). | Intranuclear inclusions, Cowdry's type A, are formed in neurons located in the edematous neuropil background (HE). Histologic features of VZV encephalitis are indistinguishable from those of HSV encephalitis. | |
 |
||
| A monoclonal antibody to GP-1 antigen of VZV demonstrates membrane positivity in the infected area (immunostaining). GP-1 antigen is not expressed in the intranuclear inclusions. | ||
|
|
||
 |
||
|
|
||
