Case 112. Creuzfeldt-Jakob's disease (60 y-o F)
         
   
Autopsied brain from a patient with progressive dementia and ankylosis
   
         
   
Key words : prion, Creutzfeldt-Jakob's disease, spongiform encephalopathy, prion
   
     
 
     
A horizontal section of the brain after formalin fixation. Diffuse cortical atrophy and ceroid pigmentaion in the cerebral cortex and basal ganglia are observed (gross findings).   The cerebral cortex shows diffuse and severe gliosis. Spongy state is seen in the deep cortex (Luxol fast blue-HE, low power).
     
   
     
The spongy state is typically observed in the deep part of the cerebral cortex (LFB-HE, high power). Spongiform encephalopathy represents a histological feature of prion disease.