Case 87. Candidosis of lung (55 y-o M)
         
    Fatal severe pneumonia in a septicemic patient after chemotherapy for lung cancer    
         
   
Key words : Candida albicans, lung abscess
   
         
   
opportunistic infection
   
     
 
     
Sausage-shaped chains of pseudohyphae of Candida albicans show deep basophilia and vacuolation at the site of junctions. Hyphae formation predominates in such a destructive, invasive lesion.   Grocott's silver strongly stains the pseudohyphae, except for the junctional vacuolation.
     
 
     
Reference case 87A
Severe bronchopneumonia seen in case of advanced gastric cancer (HE). The etiology of pneumonia is not easily recognized in H&E preparation.
  Reference case 87A
Yeast form (blastospores) of Candida albicans phagocytized by neutrophils and macrophages (PAS). PAS stain is useful to identify yeast-form fungi phagocytized by phagocytic cells in this pneumonia lesion.
     
 
     
Reference case 87B
Bronchopneumonia with foreign body granulomatous reaction against aspirated Candidal blastospores in case of advanced colon cancer (HE). C. albicans usually provokes neutrophilic cellular reation. In this case, the fungi are seen in the center of suppurative granuloma.
  Reference case 87C
Sputum cytology, presenting numerous blastospores of Candida albicans in case of oral candidosis (thrust) (Papanicolaou). In this case, no hyphae are recognized at all, indicating a mucosal surface infection of this dimorphic fungi.