Case 53. 
E. coli-induced xanthogranulomatous cholecystitis (45 y-o M)
         
    Surgical specimen of acute cholecystitis, under suspicion of possible cancer association    
         
   
Key words :  xanthogranuloma, E. coli, cholecystitis
   
     
 
     
Cut surface reveals yellow-colored nodules formed in the thickened and ulcerated gallbladder wall.   Marked accumulation of foamy macrophages is seen in the thickened gallbladder wall (HE).
     
 
     
E. coli antigens are demonstrated in the cytoplasm of foamy macrophages accumulated in the xanthogranulomatous lesion (immunostaining).   Reference case 53A
Xanthogranulomatous cholangitis, surgically resected under suspition of liver neoplasm. Yellow-colored lesion is formed in the wall of the intrahepatic bile duct (gross findings).
     
 
     
Reference case 53A
Xanthogranulomatous cholangitis, surgically resected under suspition of liver neoplasm. Xanthogranulomatous lesion is formed in the wall of the large-sized intrahepatic bile duct (HE, low power).
  Reference case 53A
Xanthogranulomatous cholangitis, surgically resected under suspicion of liver neoplasm. Xanthogranulomatous lesion in the wall of the large-sized intrahepatic bile duct (HE, high power).
     
   
     
Reference case 53A
Xanthogranulomatous cholangitis, surgically resected under suspition of liver neoplasm. E. coli antigens are demonstrated in the cytoplasm of foamy macrophages accumulated in the xanthogranulomatous lesion (immunostaining).