Case 30. Syphilis of stomach, secondary (32 y-o M)
　 　 　 　 　
　 　
Gastric biopsy from a patient with irregular-shaped, multifocal ulcer
 　 　
　 　 　 　 　
　 　
Key words : Treponema pallidum, secondary syphilis, gastritis, glossitis
 　 　
　 　 　
　
　 　 　
Dense infiltration of lymphocytes and plasma cells is seen, with gland structures destroyed (HE). 　 Treponema pallidum antigen-positive spiral mirobes are seen in the inflamed lamina propria (immunostaining)
　 　 　
　
　 　 　
Reference case 30A
Tertiary syphilis in the gastric wall (30 y-o F).　Surgical specimen of congenital syphilis accompanying a stenotic antral lesion and granulomatous reaction (HE). 		　 Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M).　Papillomatous squamous growth is associated with chronic active inflammation (HE, low power).
　 　 　
　
　 　 　
Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M).　Treponema pallidum antigen positivity is clustered multifocally in the basal part of the acanthotic squamous mucosa (immunostaining, low power).		 　 Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M).　Numerous coiled Spirochetae are seen among the inflamed squamous epithelium (immunostaining, high power).