Case 30. Syphilis of stomach, secondary (32 y-o M)
         
   
Gastric biopsy from a patient with irregular-shaped, multifocal ulcer
   
         
   
Key words : Treponema pallidum, secondary syphilis, gastritis, glossitis
   
     
 
     
Dense infiltration of lymphocytes and plasma cells is seen, with gland structures destroyed (HE).   Treponema pallidum antigen-positive spiral mirobes are seen in the inflamed lamina propria (immunostaining)
     
 
     
Reference case 30A
Tertiary syphilis in the gastric wall (30 y-o F). Surgical specimen of congenital syphilis accompanying a stenotic antral lesion and granulomatous reaction (HE).
  Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M). Papillomatous squamous growth is associated with chronic active inflammation (HE, low power).
     
 
     
Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M). Treponema pallidum antigen positivity is clustered multifocally in the basal part of the acanthotic squamous mucosa (immunostaining, low power).
  Reference case 30B
Secondary syphilis showing a papillomatous tongue lesion in AIDS (34 y-o M). Numerous coiled Spirochetae are seen among the inflamed squamous epithelium (immunostaining, high power).