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Case 18. Isospora
belli infection (45
y-o M)
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| Duodenal biopsy from a patient suffering from a long-standing intractable diarrhea | |||||
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Key words :
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Isospora belli, intractable enteritis, celiac disease, microsporidiosis | ||||
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| Severe chronic inflammation with shortening of the duodenal villi (HE) | Schizonts are distributed among the intestinal columnar epithelium (HE). Eosinophils are increased in the mucosa. | |
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| Schizonts and merozoites are seen among the intestinal epithelium (HE). | Patient's own serum diluted at 1:100 detects the protozoan pathogens among the epithelium (immunostaining = indirect immunoperoxidase). | |
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| Reference case 18A Celiac disease (gluten intolerance), duodenal biopsy from a 25 y-o African. Marked duodenal inflammation and villous atrophy are seen, but without accompanying pathogens (HE). |
Reference case 18B Microsporidiosis (Encephalitozoon cuniculi infection) in an ascites macrophage of the immunosuppressed mouse. Finely granulated pathogens are clustered in the macrophage (Gomori's trichrome). |
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| Reference case 18C Microsporidiosis (Enterocytozoon bieneusi infection) opportunistically infected in AIDS. Electron micrograph of the duodenal epithelium containing a cluster of tear drop-shaped spores which contain coiled polar tubules. |
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