Case 17. Whipple's disease (52 y-o M)
         
    Duodenal biopsy from a patient suffering from a long-standing intractable diarrhea and protein-losing enteropathy    
         
   
Key words : 
Whipple's disease, Tropheryma whippeli, foam cell, non-tuberculous Mycobacterium    
     
 
     
Endoscopic findings of the duodenal mucosa showing marked and diffuse redness and yellow spot formation   Marked accumulation of foamy macrophages and lymphangiectasia in the lamina propria mucosae (HE, low power)
     
 
     
Marked accumulation of foamy macrophages and lymphangiectasia in the lamina propria mucosae (HE, high power)   Strong PAS reactivity seen in the foamy macrophages accumulated in the lamina propria mucosae (PAS). This represents intracellular proliferation of Tropheryma whippeli
     
 
     
Reference case 17A
Non-tuberculous Mycobacterium (M. avium-intracellulare) infection in AIDS (36 y-o M).
Autopsied jejunum with marked accumulation of finely basophilic macrophages with striated cytoplasm (HE)
  Reference case 17A
Non-tuberculous Mycobacterium (M. avium-intracellulare) infection in AIDS (36 y-o M).
The cytoplasm of the striated macrophages is filled with acid-fast bacilli (Ziehl-Neelsen)