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Case 17. Whipple's
disease (52 y-o M)
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| Duodenal biopsy from a patient suffering from a long-standing intractable diarrhea and protein-losing enteropathy | |||||
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Key words :
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Whipple's disease, Tropheryma whippeli, foam cell, non-tuberculous Mycobacterium | ||||
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| Endoscopic findings of the duodenal mucosa showing marked and diffuse redness and yellow spot formation | Marked accumulation of foamy macrophages and lymphangiectasia in the lamina propria mucosae (HE, low power) | |
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| Marked accumulation of foamy macrophages and lymphangiectasia in the lamina propria mucosae (HE, high power) | Strong PAS reactivity seen in the foamy macrophages accumulated in the lamina propria mucosae (PAS). This represents intracellular proliferation of Tropheryma whippeli | |
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| Reference case 17A Non-tuberculous Mycobacterium (M. avium-intracellulare) infection in AIDS (36 y-o M). Autopsied jejunum with marked accumulation of finely basophilic macrophages with striated cytoplasm (HE) |
Reference case 17A Non-tuberculous Mycobacterium (M. avium-intracellulare) infection in AIDS (36 y-o M). The cytoplasm of the striated macrophages is filled with acid-fast bacilli (Ziehl-Neelsen) |
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